Current medicinal chemistryMar 29, 2022

Advances in Cancer-Fighting, Infection-Fighting, and Inflammation-Reducing Effects of Seven-Membered Ring Compounds

Alzheimers & Treatments Weekly Brief ↗PubMed ↗DOI ↗

Updated Apr 4, 2026

Abstract

Seven-membered heterocyclic compounds are associated with various biological activities and have been significant in drug development over the past 30 years.

These compounds contain nitrogen, oxygen, and sulfur heteroatoms.
They have demonstrated antitumor, antibacterial, and anti-inflammatory activities.
Research in the last decade highlights advances in their potential therapeutic uses.
Findings may aid in the development and design of new drugs for specific medical indications.

Simplified

Seven-membered heterocyclic compounds are important drug scaffolds because of their unique chemical structures. They widely exist in natural products and show a variety of biological activities. They have been used commonly in central nervous system drugs in the past 30 years. In the past decade, many studies have been conducted on their activities, including antitumor, antibacterial, etc. Herein, we summarize the research advances in different kinds of seven-membered heterocyclic compounds containing nitrogen, oxygen, and sulfur heteroatoms with antitumor, antisepsis, and anti-inflammation activities in the past ten years, which are expected to be beneficial to the development and design of novel drugs for the corresponding indications.

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Advances in Cancer-Fighting, Infection-Fighting, and Inflammation-Reducing Effects of Seven-Membered Ring Compounds

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