A Review on the Antitumor Activity of Various Nitrogenous-based Heterocyclic Compounds as NSCLC Inhibitors

Mar 14, 2019Mini reviews in medicinal chemistry

Antitumor Effects of Different Nitrogen-Based Ring Compounds Against Non-Small Cell Lung Cancer

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Abstract

Lung cancer accounts for approximately 15% of all cancer cases worldwide.

Non-Small Cell Lung Carcinomas (NSCLCs) represent about 80% of lung cancer cases.
Patient compliance in lung cancer treatment has been declining due to drug resistance and adverse effects.
Nitrogen-containing heterocyclic compounds are associated with a wide range of biological activities, particularly antitumor effects.
The review highlights the significant potential of nitrogen heterocycles as multi-target-directed inhibitors for NSCLCs.
There is a need for innovative structural agents to inhibit NSCLCs effectively.

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At present, cancers have been causing deadly fears to humans and previously unpredictable losses to health. Especially, lung cancer is one of the most common causes of cancer-related mortality accounting for approximately 15% of all cancer cases worldwide. While Non-Small Cell Lung Carcinomas (NSCLCs) makes up to 80% of lung cancer cases. The patient compliance has been weakening because of serious drug resistance and adverse drug effects. Therefore, there is an urgent need for the development of novel structural agents to inhibit NSCLCs. Nitrogen-containing heterocyclic compounds exhibit wide range of biological properties, especially antitumor activity. We reviewed some deadly defects of clinical medicines for the lung cancer therapy and importance of nitrogen based heterocyclic derivatives against NSCLCs. Nitrogen heterocycles exhibit significant antitumor activity against NSCLCs. Nitrogen heterocyclic hybrids could be developed as multi-target-directed NSCLC inhibitors and it is believed that the review is significant for rational designs and new ideas in the development of nitrogen heterocyclic-based drugs.

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A Review on the Antitumor Activity of Various Nitrogenous-based Heterocyclic Compounds as NSCLC Inhibitors

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