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Aqp4 stop codon readthrough facilitates amyloid-β clearance from the brain
Aqp4 protein production beyond the usual stop helps clear amyloid-β from the brain
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Abstract
The Aquaporin 4 variant AQP4X mediates amyloid beta clearance in the brain.
- Aquaporin 4 is involved in the clearance of amyloid beta, with its perivascular fraction decreased in Alzheimer's disease.
- An elongated variant of Aquaporin 4, AQP4X, is generated through a stop codon readthrough event and is found exclusively in perivascular regions.
- AQP4X has been shown to mediate the clearance of amyloid beta based on findings from knockout mice.
- Small molecule compounds that enhance the readthrough of the Aquaporin 4 sequence have been identified through high-throughput screening.
- In vivo experiments demonstrate that these compounds enhance brain amyloid beta clearance, relying on the presence of AQP4X.
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