Full text is available at the source.
Arbutin may reduce depression by lowering brain inflammation and changing gut bacteria
Updated
Abstract
Arbutin (AR) alleviated depressive-like behaviors in mice induced by chronic unpredictable mild stress.
- AR reduced neuroinflammation and oxidative stress in the mice model.
- The treatment restored levels of neurotrophic factors and gut tight junction proteins.
- AR was associated with changes in gut microbiota, specifically enriching muribaculaceae.
- Tryptophan metabolism was influenced by AR, affecting the expression of Tryptophan Hydroxylase 1 (TPH1) and Indoleamine 2,3-Dioxygenase 1 (IDO1).
- Molecular docking studies suggest that AR may bind to TPH1 and IDO1.
Simplified