Efficacy of Aripiprazole Against Hostility in Schizophrenia and Schizoaffective Disorder

Aripiprazole was superior to placebo in reducing hostility in 1,476 patients.

• The studies involved patients diagnosed with schizophrenia or schizoaffective disorder.
• Five short-term, double-blind studies were conducted to compare aripiprazole with placebo and haloperidol.
• The Positive and Negative Syndrome Scale (PANSS) was used to assess outcomes related to hostility.
• Post hoc analyses focused on the hostility item from the PANSS for the first four weeks of treatment.
• Aripiprazole was not significantly different from haloperidol in its effects on hostility.

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