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Abstract
The Arp2/3 complex is crucial in the later stages of autophagy, particularly for maintaining lysosomal integrity.
- Actin cytoskeletal rearrangements are influenced by the Arp2/3 complex during the autophagy process.
- The role of Arp2/3-mediated actin assembly in autophagy has been previously unclear.
- WHAMM promotes the activation of Arp2/3 at permeabilized lysosomes.
- New roles for actin, the Arp2/3 complex, and WHAMM in lysosomal damage responses are identified.
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