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Artificial Lighting in the Industrialized World: Circadian Disruption and Breast Cancer
Artificial Light at Night, Body Clock Disruption, and Breast Cancer Risk in Industrialized Societies
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Abstract
Breast cancer risk may increase due to circadian disruption associated with modern lifestyles.
- Circadian disruption is linked to changes in melatonin production and affects the molecular timing of the circadian clock.
- Stronger endogenous melatonin rhythms are observed in individuals exposed to brighter daytime environments.
- Light intensity required to suppress melatonin at night is decreasing, suggesting increased sensitivity to light.
- Melatonin suppression in animal studies is associated with increased breast tumor development.
- Maintaining a natural day-night light cycle could support healthier melatonin and clock gene expression.
- Exogenous melatonin administration may disrupt circadian rhythms instead of correcting them, depending on the timing of doses.
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