We can’t show the full text here under this license. Use the link below to read it at the source.
Asiatic Acid-Loaded Hydrogel Ameliorates Diabetic Periodontitis via Mitophagy-Mediated M2 Macrophage Polarization
Gel with Asiatic Acid may Improve Diabetic Gum Disease by Helping Immune Cells Clear Damaged Mitochondria and Shift to Healing Mode
AI simplified
Abstract
The AA@GO hydrogel significantly increased the M2/M1 polarization ratio in macrophages.
- A bidirectional relationship between diabetes and periodontitis may exist, with shared pathogenic mechanisms.
- Asiatic acid (AA) is a compound known for its antioxidant and anti-inflammatory properties.
- The hybrid hydrogel AA@GO effectively enhances , reduces intracellular reactive oxygen species (ROS) levels, and restores mitochondrial function in macrophages.
- Macrophages treated with AA@GO showed a phenotype switch from M1 to M2, leading to reduced inflammation.
- The findings suggest that modulating with AA@GO could offer a novel approach to treating diabetic periodontitis.
AI simplified
Key numbers
17×
M2/M1 Polarization Ratio Increase
AA@GO hydrogel treatment led to a 17× increase in the M2/M1 ratio.
50%
Reduction in Alveolar Bone Loss
AA@GO treatment resulted in a 50% reduction in alveolar bone loss in diabetic periodontitis mice.