Link Between Sleep Timing Problems and Noninfectious Eye Inflammation

Circadian misalignment may influence factors related to noninfectious uveitis (NIU).

• Circadian misalignment is linked to disruptions in ocular immune balance.
• Inflammatory signaling and blood-retinal barrier integrity may be affected by circadian misalignment.
• The relationship between clinically diagnosed circadian rhythm sleep-wake disorder (CRSD) and the onset of NIU is currently unclear.
• This examination utilized a large multicenter cohort to investigate the potential association.

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