Association between exposure to rotating night shift versus day shift using levels of 6-sulfatoxymelatonin and cortisol and other sex hormones in women

Rotating night-shift workers had lower excretion of 6-sulfatoxymelatonin compared to day-shift workers.

• Average aMT6s excretion was 50.26 ng aMT6s/mg creatinine in night-shift workers versus 88.79 ng aMT6s/mg creatinine in day-shift workers.
• Night-shift workers exhibited lower fluctuation in aMT6s levels, with an amplitude of 45.24 ng aMT6s/mg creatinine compared to 79.71 ng aMT6s/mg creatinine in day-shift workers.
• The peak time for aMT6s secretion occurred later in night-shift workers at 08:31 compared to 07:13 in day-shift workers.
• Higher levels of estradiol and progesterone were observed in night-shift workers relative to day workers, particularly during the follicular phase of the menstrual cycle.

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