Frontiers in pharmacology

Astragalus polysaccharide may reduce brain damage and memory problems by changing gut bacteria and brain inflammation in Alzheimer's disease

Gut-Brain Axis Weekly Brief ↗PubMed ↗DOI ↗OA ↗

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Abstract

Neuroprotective effects of Astragalus polysaccharides may delay progression of Alzheimer's disease.

  • Astragalus polysaccharides are derived from traditional Chinese herbs.
  • Effects were assessed in 5×FAD transgenic mice, a model for Alzheimer’s disease.
  • Cognitive impairment and neuropathology were targeted as key areas of investigation.
  • The study focused on the potential regulatory role of the gut-brain axis.

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