Neurochemical research

How Brain Support Cells Clear Waste in Neurodegenerative Diseases: Recent Advances in Understanding and Treatment

Updated

Abstract

Astrocyte autophagy is linked to neurodegenerative disorders such as Alzheimer's and Parkinson's disease.

  • Astrocytes are essential for maintaining brain cell health and supporting neurons.
  • Autophagy helps remove damaged proteins and organelles from cells, but its role in astrocytes is less studied than in neurons.
  • Astrocyte autophagy may influence the progression of neurodegenerative disorders by modulating oxidative stress and inflammation.
  • The process is associated with the management of protein aggregation and misfolding in conditions like Alzheimer's and Huntington's diseases.
  • Certain medications could potentially target astrocyte autophagy pathways to prevent or treat neurodegenerative diseases.

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Competing interests

Declarations. Competing Interest: The authors declare no competing interests. Ethical Approval and Consent to Participate: None. Consent for Publication: None.
PubMed

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