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Astrocytes: From the Physiology to the Disease
Astrocytes: Their Normal Functions and Role in Disease
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Abstract
Abnormalities in astrocytic function are involved in the pathogenesis of multiple neurodegenerative diseases.
- Astrocytes play critical roles in brain formation, blood flow regulation, and neuronal metabolism.
- They are associated with neurotransmitter synthesis, exocytosis, and synaptic transmission.
- Emerging evidence suggests that astrocytic dysfunction may contribute to Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, and Amyotrophic Lateral Sclerosis.
- The review highlights astrocytes' physiological roles and their communication with other brain cells.
- New experimental approaches are discussed that could shed light on astrocyte involvement in neurological disorders.
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