Open medicine (Warsaw, Poland)

Stem cells with extra ATG5 help ligament healing by promoting healing-type immune cells in older rats

Updated

Abstract

Autophagy is crucial for maintaining mesenchymal stem cell (MSC) function.

  • Age-related deficits in ligament healing may be linked to changes in MSC autophagic activity.
  • The role of autophagy in MSC function is not fully understood.
  • Overexpression of a protein involved in autophagy, ATG5, was evaluated for its potential effects on healing and regeneration.

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