AtHDA15 binds directly to COP1 positively regulating photomorphogenesis

AtHDA15 positively regulates photomorphogenesis by binding to COP1, a key repressor of light-regulated growth.

• Histone acetylation and deacetylation are important for light-regulated gene expression during seedling development.
• Knock-out and RNAi lines of hda15 display light hyposensitivity and longer hypocotyls in the dark due to decreased levels of HY5 and PIF3 proteins.
• Overexpression of AtHDA15 increases HY5 concentrations, resulting in shorter hypocotyls.
• In vivo and in vitro assays indicate that HDA15 directly interacts with COP1 in the nucleus.
• The interaction between HDA15 and COP1 may alter COP1's repressive functions under different light conditions.

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