Global research trends in atherosclerosis-related NF-κB: a bibliometric analysis from 2000 to 2021 and suggestions for future research

Feb 23, 2023Annals of translational medicine

Worldwide research patterns on the role of NF-κB in artery disease from 2000 to 2021 and future research ideas

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Abstract

A total of 5,439 articles on NF-κB in atherosclerosis were analyzed from 2000 to 2021.

The annual publication rate on NF-κB in atherosclerosis has shown fluctuations, increasing overall over the past 22 years.
China was the leading country in terms of the number of publications, while the USA had the highest citation counts.
The University of California System was identified as the most productive institution, and the journal Arteriosclerosis Thrombosis and Vascular Biology published the most papers.
Recent keywords like 'nlrp3 inflammasome' and 'microRNA' indicate emerging research trends in the field.
Studies have increasingly highlighted the regulatory role of NF-κB in atherosclerosis, suggesting it may serve as a therapeutic target.

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BACKGROUND: Atherosclerosis (AS) is closely related to stroke and cardiovascular diseases. Nuclear factor kappa-B (NF-κB) is the master regulator of inflammation, and thus, modulating the transcription of NF-κB can improve AS.

METHODS: In this study, we conducted a bibliometric analysis to identify the frontiers, hotspots, and features of global research output on NF-κB in AS from 2000 to 2021. Papers published from 2000 to 2021 and the recorded information were retrieved from the Science Citation Index-Expanded of the Web of Science Core Collection. Bibliometric analysis and visualization were performed using VOSviewer and CiteSpace, including an analysis of the general distribution of annual output, highly productive countries, active journals, active institutions and authors, keywords, and co-cited references.

RESULTS: A total of 5,439 original articles and reviews were retrieved and analyzed, and the results indicated that the annual number of publications on NF-κB in AS has been increasing in waves over the past 22 years. The majority of papers were published in China, while the USA had the highest number of citations and H-index. The most productive affiliation and journal were the University of California System and Arteriosclerosis Thrombosis and Vascular Biology, respectively. The papers of Chiu JJ. received the highest number of citations globally in 2011. The keywords, "nlrp3 inflammasome" and "microRNA", have recently attracted considerable attention, and very frequently occurring keywords included "NF kappa B", "atherosclerosis", "expression", "activation", "endogenous cell", and "oxidative stress". New keywords in 2021 included "muscle", "attenuates atherosclerosis", "mesenchymal transition", "metabolic disorder", and "palmitic acid".

CONCLUSIONS: AS and inflammation have become research hotspots lately. Over the past decade, most studies have focused on basic research, and pathways associated with the regulatory role of NF-κB in AS have become a particular focus in recent studies. Moreover, our study revealed that NF-κB plays a remarkable role in AS and may be a therapeutic target.

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Global research trends in atherosclerosis-related NF-κB: a bibliometric analysis from 2000 to 2021 and suggestions for future research

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