Reducing cell cleaning activity in the emotion system may ease anxiety behaviors in mice with PTSD

Reducing autophagy in the amygdala was linked to less anxiety-like behavior in PTSD model mice.

Animal experiments in wild-type and Fmr1 knockout mice manipulated autophagy across the amygdala, medial prefrontal cortex, and hippocampus in a PTSD mouse model.

The findings are limited to mouse anxiety-like behaviors and region-specific autophagy manipulations, not human PTSD outcomes.