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Restoring autophagy flux by rolipram attenuates ototoxicity in Hearing loss
Rolipram may reduce hearing loss by improving cell cleanup processes
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Abstract
Enhancing autophagy with rolipram significantly improved cell survival and preserved cochlear hair cells in the presence of kanamycin and furosemide.
- Sensorineural hair cell loss is a major contributor to hearing loss.
- Failure of autophagy flux is associated with impaired hearing in ototoxic conditions.
- Rolipram treatment restored autophagy activity and improved cell viability in a dose-dependent manner.
- The protective effect of rolipram was negated by chloroquine or Atg7 knockdown, indicating the necessity of intact autophagy flux for cellular protection.
- In vivo, rolipram reduced hearing loss and maintained both cochlear hair cells and ribbon synapses of inner hair cells.
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