How Cell Recycling Controls Immune Cell Survival by Managing Metabolism and a Combined Cell Death Process

Autophagy influences immune cell differentiation and fate decisions by regulating metabolic reprogramming.

• Autophagy acts as a molecular switch that modulates the differentiation of immune cells.
• It eliminates intracellular danger signals, which influences whether immune cells undergo PANoptosis.
• PANoptosis integrates features of pyroptosis, apoptosis, and necroptosis, leading to inflammatory cell death.
• Mitophagy, a specific type of autophagy, helps prevent excessive activation of PANoptosis by degrading danger signals.
• Dysregulation of autophagy can lead to inflammatory responses and immunopathological damage.

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