Full text is available at the source.
Abstract
A specialized variant of autophagy, known as nucleophagy, actively removes PARP1 molecules from DNA during pharmacological inhibition.
- Autophagy is linked to various mechanisms that allow cancer cells to evade the immune system.
- Nucleophagy may contribute to cytoprotection by removing PARP1 molecules that are trapped on DNA.
- The process of nucleophagy could also be associated with immunosuppressive effects in the context of cancer.
Simplified