Future medicinal chemistry

Targeting enzymes that control cell recycling: from how they work to new small-molecule treatments

Updated

Abstract

Autophagy is an evolutionarily conserved process that recycles damaged organelles and macromolecules.

  • Autophagy is involved in various physiological and pathological processes.
  • Protein kinases play essential roles in regulating different stages of autophagy.
  • These kinases are critical for signal transduction and the regulation of cellular processes.
  • Autophagy-associated protein kinases may serve as potential therapeutic targets for human diseases.
  • Small-molecule compounds targeting these kinases could offer promising therapeutic strategies.

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Funding

Competing interests

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
PubMed

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