Does autophagy play a key role in the protective effect of oleic acid against oxidative stress in endothelial cells?

Oleic acid within the micromolar range stimulated autophagy in endothelial cells.

• Endothelial dysfunction is linked to cardiovascular complications and atherosclerosis.
• Oxidative stress is identified as a mechanism contributing to endothelial dysfunction.
• Preventing oxidative stress may help avoid endothelial dysfunction and related cardiovascular diseases.
• Oleic acid has demonstrated the ability to reduce reactive oxygen species and oxidative stress.
• Inhibition of autophagy in stressed endothelial cells showed minimal changes in the protective effects of oleic acid.
• The findings indicate that autophagy has a limited role in the protective mechanism of oleic acid during severe oxidative stress.

AI simplified