Full text is available at the source.
Abstract
Chronic low-grade inflammation is linked to the disruption of the bone marrow microenvironment in osteoporosis.
- Imbalanced bone formation and resorption is a key feature of osteoporosis.
- NLRP3 inflammasome-mediated pyroptosis may enhance local inflammation.
- This process could lead to the release of inflammatory molecules such as IL-1β and IL-18.
- Damage-associated molecular patterns may also be released during this inflammatory response.
- Mitophagy may play a role in controlling inflammation by ensuring mitochondrial quality and reducing oxidative stress.
Simplified