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Differential roles of AVP and VIP signaling in the postnatal changes of neural networks for coherent circadian rhythms in the SCN
Different roles of two brain signals in developing daily rhythm networks after birth
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Abstract
Vasoactive intestinal polypeptide (VIP) signaling is essential for the tissue-level circadian rhythm in the neonatal suprachiasmatic nucleus of CRY double-deficient mice.
- The suprachiasmatic nucleus (SCN) serves as the master circadian clock in mammals.
- Changes in the SCN network are observed postnatally in mice, specifically involving clock gene products.
- In CRY double-deficient mice, both VIP and arginine vasopressin (AVP) signaling contribute redundantly to the circadian rhythm.
- AVP synthesis is significantly reduced in the SCN of CRY double-deficient mice, which may lead to irregular rhythms in adult mice.
- The integration of cellular circadian rhythms in the SCN varies based on the postnatal developmental stage.
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