We can’t show the full text here under this license. Use the link below to read it at the source.
Landscapes of bacterial and metabolic signatures and their interaction in major depressive disorders
Patterns of bacteria and metabolic changes and their interaction in major depression
AI simplified
Abstract
A total of 100 microbial and viral species and metabolites showed significant differences between major depressive disorder (MDD) patients and healthy controls.
- Three bacteriophages, 47 bacterial species, and 50 fecal metabolites exhibited notable differences in abundance.
- MDD patients were characterized by increased levels of certain bacterial genera and decreased levels of others.
- Alterations in microbial genes and metabolites were linked to the metabolism of specific amino acids, including γ-aminobutyrate, phenylalanine, and tryptophan.
- A marker panel was identified that could effectively distinguish MDD patients from healthy individuals in both discovery and validation sets.
- The findings suggest complex interactions within the , virome, and in the context of MDD.
AI simplified
Key numbers
18 of 47
Bacterial Species Change
Patients with MDD show increased abundance of 18 bacterial species.
16 of 50
Fecal Metabolites Change
MDD patients display enrichment in 16 metabolites compared to HCs.
0.98
Diagnostic Performance
AUC of the combinatorial marker panel in the discovery set.