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Abstract
PHR2 from Chrysodeixis chalcites nucleopolyhedrovirus can bind to the CLOCK protein and repress transcription driven by the CLOCK/BMAL1 heterodimer.
- Cryptochromes and photolyases, although structurally similar, have different functions in organisms.
- Photolyases repair DNA damage caused by ultraviolet light, while cryptochromes are involved in circadian rhythm regulation.
- PHR1 and PHR2, two photolyase-like genes, can bind to the CLOCK protein.
- Only PHR2's interaction with CLOCK inhibits CLOCK/BMAL1-driven transcription.
- PHR2 influences the circadian rhythms in immortalized mouse embryonic fibroblasts.
- These results may contribute to understanding the evolutionary relationship between cryptochromes and photolyases.
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