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Bao Yuan decoction and Tao Hong Si Wu decoction improve lung structural remodeling in a rat model of myocardial infarction: Possible involvement of suppression of inflammation and fibrosis and regulation of the TGF-β1/Smad3 and NF-κB pathways
Bao Yuan and Tao Hong Si Wu herbal treatments improve lung damage after heart attack in rats by reducing inflammation and scarring through specific cell signaling pathways
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Abstract
Treatment with Bao Yuan decoction combined with Tao Hong Si Wu decoction (BYTH) normalized lung weight in rats after myocardial infarction.
- Chronic heart failure is associated with pulmonary structural remodeling that contributes to poor clinical outcomes.
- BYTH treatment reduced levels of type I collagen, TGF-β1, and α-SMA expression in the lungs following myocardial infarction.
- The therapy decreased phosphorylation of Smad3 and lowered levels of inflammatory mediators such as TNF-α, TLR4, and NF-κB.
- Results indicate that BYTH may improve lung structural remodeling via anti-inflammatory and anti-fibrotic actions.
- The potential mechanisms of action could involve suppression of TGF-β1/Smad3 and NF-κB signaling pathways.
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