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BBSome ablation in SF1 neurons causes obesity without comorbidities
Removing BBSome from hormone-controlling neurons leads to obesity without other health problems
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Abstract
SF1/Bbs1 mice exhibited a significant increase in body weight and adiposity under normal chow conditions.
- Food intake, energy absorption, and digestive efficiency remained unchanged despite Bbs1 gene deletion in SF1 neurons.
- Energy expenditure was notably lower in SF1/Bbs1 mice, especially during the dark cycle.
- Reduced sympathetic nerve traffic and decreased markers of thermogenesis were observed in brown adipose tissue of SF1/Bbs1 mice.
- Lower sympathetic nerve activity to subcutaneous white adipose tissue was associated with a protein expression profile that promotes lipid accumulation.
- SF1/Bbs1 mice did not show significant changes in glucose metabolism, insulin sensitivity, blood pressure, or baroreflex sensitivity despite obesity and hyperinsulinemia.
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