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Regulation of behavioral circadian rhythms and clock protein PER1 by the deubiquitinating enzyme USP2
How the enzyme USP2 controls daily behavior rhythms and the clock protein PER1
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Abstract
Mice lacking the Usp2 gene exhibit a longer free-running period of locomotor activity rhythms.
- Deletion of the Usp2 gene leads to altered responses of the circadian clock to light.
- Changes in Usp2 KO mice are associated with altered expression of clock genes in their embryonic fibroblasts.
- Increased levels of the clock protein PERIOD1 (PER1) are observed in Usp2 KO mice.
- USP2 interacts specifically with PER1 and deubiquitinates it without affecting its stability.
- These findings suggest that USP2 is a key component of the circadian clock regulation.
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Key numbers
7.0±1.1 d
Increased free-running period
KO mice took longer to adjust to a 6-hour advance in light cycle.
4 per time point
Altered gene expression
Peak mRNA levels of clock genes were reduced in KO MEFs.