We can’t show the full text here under this license. Use the link below to read it at the source.
β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease
Beta-amyloid triggers inflammation by binding to immune receptors in Alzheimer's disease
AI simplified
Abstract
Knockout of Dectin-1 reduced Aβ1-42-induced microglial activation and cognitive deficits in Alzheimer’s disease mice.
- Dectin-1 on microglia mediates pro-inflammatory responses to beta-amyloid.
- Deletion of Dectin-1 led to decreased inflammatory responses in Aβ-infused Alzheimer’s disease mice.
- Aβ can bind to Dectin-1, triggering a signaling pathway that activates inflammation.
- Activation of the spleen tyrosine kinase/nuclear factor-κB signaling pathway is associated with increased expression of inflammatory factors.
- These findings highlight Dectin-1's role in microglial activation related to Alzheimer’s disease pathology.
AI simplified