Reproduction (Cambridge, England)Sep 4, 2026

Changing Fertility Timing in Women with Reduced Egg Supply

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Sep 5, 2026

Abstract

Diminished Ovarian Reserve (DOR) is associated with significant impacts on fertility and quality of life.

Key molecular events linked to DOR include telomere shortening, mitochondrial dysfunction, and epigenetic changes.
Current clinical diagnostic criteria and emerging biomarkers for DOR are summarized.
Limitations of existing treatment strategies for DOR are examined.
Potential interventions based on aging reprogramming are discussed.

Simplified

Diminished Ovarian Reserve (DOR) is a significant manifestation of female reproductive aging that profoundly impacts fertility and quality of life. In recent years, the emergence of aging reprogramming technologies has provided new insights into the mechanisms underlying DOR and potential therapeutic approaches. This review synthesizes current knowledge on the role of aging reprogramming in DOR, focusing on key molecular events such as telomere shortening, mitochondrial dysfunction, and epigenetic alterations. Furthermore, we summarize clinical diagnostic criteria and emerging biomarkers for DOR, while exploring the limitations of existing treatment strategies and the potential interventions based on aging reprogramming. By addressing these issues, this review aims to highlight the interplay between aging processes and ovarian function, paving the way for innovative therapeutic avenues to improve reproductive health in women experiencing DOR.

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Changing Fertility Timing in Women with Reduced Egg Supply

Abstract

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