A Case Report of Bezoar-Induced Small Bowel Obstruction: A Potential Surgical Complication of Semaglutide

Dec 23, 2025Cureus

A Case of Small Intestine Blockage Caused by Bezoar Possibly Linked to Semaglutide Use

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Abstract

A 65-year-old woman developed a small bowel obstruction due to a large phytobezoar after using semaglutide for weight loss.

  • Bezoars can cause small bowel obstructions, but are often difficult to identify before surgery.
  • The patient experienced abdominal pain, distension, nausea, and vomiting for four days.
  • Imaging confirmed the presence of a small bowel obstruction.
  • Nonoperative management was ineffective, leading to a laparoscopic procedure that removed the obstructing bezoar.
  • Semaglutide, a GLP-1 receptor agonist, may be associated with gastroparesis and slow intestinal transit, contributing to bezoar formation.

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