Supplementation with Bifidobacterium animalis subsp. lactis MH-022 for remission of motor impairments in a 6-OHDA-induced Parkinson's disease rat model by reducing inflammation, reshaping the gut microbiome, and fostering specific microbial taxa

Aug 27, 2024Food & function

Bifidobacterium animalis supplement may reduce movement problems in a Parkinson’s rat model by lowering inflammation, changing gut bacteria, and promoting helpful microbes

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Abstract

MH-022 supplementation significantly improved motor deficits and preserved dopaminergic neurons in a rat model of Parkinson's disease.

Supplementation with MH-022 enhanced antioxidant capacity and reduced inflammation by restoring mitochondrial function.
MH-022 altered gut microbiota composition, increasing the production of short-chain fatty acids and promoting beneficial bacterial growth.
Strong correlations were found between specific bacterial types and improvements in motor function, antioxidant levels, and reduced inflammation markers.
The findings suggest that MH-022 may play a role in modulating inflammation and protecting dopaminergic neurons in Parkinson's disease.

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Inflammation significantly influences the degeneration of dopaminergic neurons in Parkinson's disease (PD), which is potentially intensified by associated gut dysbiosis. The therapeutic potential of probiotics, due to their antioxidant, anti-inflammatory, and gut microbiota modulatory properties, is explored herein as a means to improve gut health and influence the gut-brain-microbiota axis in the context of PD. In this study, we investigated the role and possible mechanism ofsubsp.MH-022 (MH-022) supplementation in a 6-hydroxydopamine (6-OHDA)-induced rat model of PD. Findings demonstrated thatMH-022 supplementation markedly ameliorated motor deficits, preserved dopaminergic neurons, enhanced the antioxidant capacity, and mitigated inflammation through restoring mitochondrial function. Furthermore,MH-022 supplementation significantly altered the gut microbiota composition, augmenting the production of short-chain fatty acids and promoting the proliferation of beneficial bacterial taxa, thereby reinforcing their anti-inflammatory properties. Correlation analyses established strong associations between specific bacterial taxa and improvements in motor function, antioxidant levels, and reductions in inflammation markers. These insights emphasize the therapeutic potential ofMH-022 in modulating diverse aspects of PD, particularly highlighting its role in reducing inflammation, restoring mitochondrial function, enhancing antioxidant capacity, and reshaping the gut microbiota. This multifaceted approach underscores the probiotic's potential in reducing neuroinflammation and protecting dopaminergic neurons, thus offering a promising avenue for PD treatment. Bifidobacterium animalis lactis B. lactis B. lactis B. lactis B. lactis

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Supplementation with Bifidobacterium animalis subsp. lactis MH-022 for remission of motor impairments in a 6-OHDA-induced Parkinson's disease rat model by reducing inflammation, reshaping the gut microbiome, and fostering specific microbial taxa

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