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Bimetallic chitosan/hyaluronic acid nanoparticles self-amplify ferroptosis/cuproptosis in triple-negative breast cancer
Metal-based nanoparticles boost two types of cell death in aggressive breast cancer
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Abstract
5FCN nanoparticles demonstrate superior cell-killing efficacy against triple-negative breast cancer (TNBC).
- 5FCN nanoparticles utilize a dual mechanism of ferroptosis and cuproptosis to target TNBC cells.
- Hyaluronic acid in 5FCN selectively binds to CD44 receptors, facilitating entry into TNBC cells.
- The release of iron and copper ions in acidic environments disrupts the antioxidant defense system in tumor cells.
- Toxic hydroxyl radicals are generated through reactions involving the released metal ions, promoting ferroptosis.
- Increased copper levels within cells lead to the aggregation of specific proteins, enhancing cuproptosis.
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