Biological Clock Genes are Crucial and Promising Biomarkers for the Therapeutic Targets and Prognostic Assessment in Gastric Cancer

Mar 1, 2024Journal of gastrointestinal cancer

Biological Clock Genes as Important Markers and Treatment Targets in Stomach Cancer

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Abstract

Only PER1, CLOCK, and TIMELESS showed statistically significant expression differences in gastric cancer compared to normal tissues (p < 0.05).

  • PER1 and CLOCK expression is associated with the pathological stage of gastric cancer.
  • High expression of PER1 and NR1D1 is linked to longer overall survival in gastric cancer patients.
  • Patients with elevated levels of PER1 and NR1D1 also experienced longer disease-free survival.
  • Circadian clock genes are primarily involved in regulating circadian rhythms and melatonin metabolism.
  • CLOCK, NPAS2, and KAT2B are identified as key transcription factors for circadian clock genes.
  • Correlations were observed between circadian clock genes and various immune cells in the gastric cancer microenvironment.

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