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Abstract
Interventions targeting conserved aging pathways can markedly extend lifespan in model organisms, but their efficacy declines with increasing organismal complexity.
- Aging in simple organisms is influenced by a limited number of significant pathways.
- In mammals, aging results from complex, multi-tissue regulatory systems that include redundancy and feedback mechanisms.
- Key factors affecting lifespan extension include metabolic organization, genetic redundancy, and endocrine regulation.
- Interactions with the microbiome and pharmacokinetic complexities also play a role in the aging process.
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