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Abstract
Cellular senescence may play a central role in the development of frailty, particularly in older adults.
- Frailty is characterized by reduced physiological resilience and increased vulnerability to stress.
- Accumulation of senescent cells in various organs disrupts normal tissue function and contributes to systemic inflammation.
- Circulating factors associated with cellular senescence may serve as indicators and contributors to frailty.
- Emerging therapies targeting senescent cells could help reduce frailty-related declines in function.
- Exploring the connection between cellular senescence and frailty may enhance risk assessment and treatment strategies.
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