Biological rhythms in bipolar and depressive disorders: A community study with drug-naïve young adults

Biological rhythm disruption was significantly higher in bipolar disorder (BD) at 40.32±9.92 and major depressive disorder (MDD) at 36.23±8.71 compared to community controls at 27.67±6.88.

• Both bipolar disorder and major depressive disorder are linked to disruptions in biological rhythms.
• Individuals with bipolar disorder exhibited higher total scores on the Biological Rhythm Interview compared to those with major depressive disorder.
• Increased disruptions in sleep and social rhythms were observed in subjects with bipolar disorder relative to those with major depressive disorder.
• Biological rhythm disruptions were noted in individuals with bipolar disorder during euthymic phases, but not in those with remitted major depressive disorder.
• Assessing biological rhythm disruptions may help in identifying mood disorder patients and differentiating between bipolar disorder and major depressive disorder.

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