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A novel biomimetic nanoplatform amplifies ferroptosis for specific cGAS-STING pathway activation to enhance hepatocellular carcinoma chemo-immunotherapy
A new cell-like nanoparticle boosts ferroptosis to activate immune defense and improve liver cancer chemo-immunotherapy
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Abstract
A novel biomimetic nanoplatform (PZ@M-T) significantly inhibited hepatocellular carcinoma (HCC) progression by specifically activating the .
- The nanoplatform triggers in HCC cells, leading to the release of mitochondrial DNA.
- Endogenous mitochondrial DNA activates the cGAS-STING pathway in a specific manner.
- Activation of the cGAS-STING pathway promotes dendritic cell maturation and repolarizes tumor-associated macrophages from M2 to M1 phenotype.
- This process enhances cytotoxic T cell infiltration while suppressing regulatory T cells.
- Collectively, these effects drive a robust anti-tumor immune response.
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Key numbers
76.7%
Tumor Inhibition Rate
Compared to 12.8% for TA-ZIF-8 and 30.2% for PPⅡ.
1.9×
Pro-inflammatory Cytokine Increase
Levels of IFN-β increased compared to control.
20.60%
Dendritic Cell Maturity
Compared to 2.86% in control group.