Using a special chemical method to attach tightly packed DNA to the cell's outer nucleus layer reverses aging and joint disease

An increase in the number of senescent cells with advancing age is a major predisposing factor for aging-related osteoarthritis.

• Cellular senescence may contribute to the development of osteoarthritis as individuals age.
• Rising epigenetic entropy is suggested as a potential driver of cellular senescence.
• The detachment of heterochromatin from the nuclear envelope is associated with increased cellular senescence.

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