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Abstract
BBB disruption (BBBD) successfully increases the delivery of antineoplastic agents to the central nervous system.
- Standard chemotherapy has limited effectiveness in treating brain tumors due to barriers in drug delivery.
- The blood-brain barrier (BBB) presents a significant challenge for the treatment of brain neoplasias.
- Innovative approaches have been developed to improve drug delivery across the BBB.
- The chapter discusses the application of BBBD in rats as a method to enhance drug delivery.
- Several techniques for evaluating BBB permeability after hyperosmolar mannitol infusion are presented.
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