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Abstract
A novel peptide capable of penetrating the blood-brain barrier may enhance treatment for glioma and breast cancer brain metastases.
- Glioma is the most common malignant tumor of the central nervous system.
- The blood-brain barrier and blood-brain tumor barrier limit drug delivery to brain tumors.
- Peptide-drug conjugates were developed from a newly identified peptide that can cross these barriers.
- Antitumor activity was observed in glioma and breast cancer brain metastases models.
- Combining the peptide-drug conjugates with temozolomide resulted in synergistic effects.
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