Higher blood-derived was associated with lower in US adults.
Evidence
This cross-sectional NHANES analysis included 14,499 adults aged 20 or older and modeled biological age, biological age acceleration, site-specific BMD, and risk.
Caveat
The observational NHANES design can show adjusted associations but cannot establish that biological aging causes lower BMD.
Simplified
OBJECTIVE: Little is known regarding the association between and (BMD). This study aimed to assess the effects of biological aging on BMD in US adults.
METHODS: This study included 14,499 adults aged 20 or older from NHANES (2005-2010, 2013-2014, and 2017-2018). Biological aging was assessed using two different approaches: biological age and biological age acceleration. Multiple linear regression was used to investigate the relationship between biological aging and BMD. Generalized additive models and smoothed curve fitting were used to examine the dose-response relationship between biological aging and BMD. Multiple logistic regression was used to investigate the relationship between biological aging and the risk of .
RESULTS: After adjusting for potential confounders, our analysis revealed a significant inverse relationship between biological age, biological age acceleration, and BMD at various sites, including the femur neck, total femur, trochanter, and intertrochanter. Furthermore, we observed a significant negative linear correlation between biological age, biological age acceleration, and BMD. Additionally, both biological age and biological age acceleration demonstrated negative associations with the risk of osteoporosis.
CONCLUSIONS: Our findings suggest a significant negative association between biological aging and BMD in US adults.
Key numbers
−0.0120
Decrease in
Adjusted for potential confounders in the analysis.
1.7170
Odds Ratio for Risk
Adjusted for various covariates in the logistic regression model.
−0.0110
Decrease in
Adjusted for multiple confounders in the analysis.
Full Text
We can’t show the full text here under this license.
