BMAL1 controls the mTOR pathway to slow down aging

BMAL1 deficiency is associated with a 50% increase in lifespan of treated mice.

• Increased activity of the mTORC1 pathway occurs with BMAL1 deficiency in both living organisms and cell cultures.
• Elevated mTOR signaling is linked to accelerated aging.
• The mTORC1 inhibitor rapamycin effectively increases lifespan in BMAL1-deficient mice.
• BMAL1 may function as a negative regulator of mTORC1 signaling.
• Circadian clock regulation of the mTOR pathway through BMAL1 could play a role in aging and metabolism.

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