Removing a Key Clock Gene in Thinking Area Nerve Cells May Cause Schizophrenia-Like Behaviors in Mice

The single nucleotide polymorphism rs1982350 in the Bmal1 gene is linked to the pathogenesis of schizophrenia.

• Circadian disturbances are frequently observed alongside schizophrenia.
• The role of clock genes in inducing schizophrenia-like behaviors in mice remains unclear.
• Bmal1 is a core circadian clock gene that regulates circadian rhythms.
• Deficits in clock genes may have implications for understanding schizophrenia.

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