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Abstract
Essence
Brain cellular senescence signatures were linked to brain structure, especially volume-related features in excitatory neurons and microglia.
Evidence
This integrative neuroimaging and molecular expression analysis used prefrontal cortex tissue from neurosurgery patients and replicated cell-type-specific signatures in independent datasets, including a brain gene expression dataset from individuals below 5 years of age.
Caveat
The work maps molecular correlations across datasets rather than showing that senescence directly causes brain atrophy or developmental brain-structure differences.
Simplified
Longevity & Aging