Brain circadian clocks timing the 24h rhythms of behavior

Mar 3, 2026Npj biological timing and sleep

Brain’s internal clocks controlling daily behavior rhythms

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Abstract

The hypothalamic (SCN) is the principal clock coordinating in mammals.

  • Multiple brain regions exhibit 24-hour activity in electrical properties, metabolic processes, and gene expression.
  • Some regions display robust, self-sustained oscillatory activity, while others rely on the SCN for rhythmicity.
  • The presence of multiple circadian clocks in the brain may enhance adaptability to environmental rhythms.
  • The review emphasizes the functional relationship between these central clocks and the SCN in regulating behavior.
  • Maintaining a network of circadian clocks could support better physiological health and behavioral adaptation.

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