Full text is available at the source.
Brain Clocks: From the Suprachiasmatic Nuclei to a Cerebral Network
Brain timekeeping: from the main body clock to the wider brain network
AI simplified
Abstract
Circadian timing affects almost all life's processes.
- The master circadian clock is located in the suprachiasmatic nuclei (SCN) of the hypothalamus.
- Extra-SCN cerebral clocks and peripheral oscillators contribute to daily variations in physiology and behavior.
- There are notable similarities and differences in the molecular mechanisms between the primary SCN clock and extra-SCN brain clocks.
- Secondary clocks in the brain may have different sensitivities to time-giving cues and vary in their connection to the SCN.
- Alterations in internal timing could lead to health issues due to desynchronization among the network of cerebral clocks.
AI simplified