Eighteen training sessions using a custom-designed exergame resulted in significant improvements in gait and balance for 11 individuals with Parkinson's disease.
The active training group experienced decreased between the sensorimotor, attentional, and basal ganglia networks.
An increase in resting-state functional connectivity was observed between the cerebellar and basal ganglia networks in the active group.
In contrast, the control group showed no significant changes in gait and balance and a decrease in resting-state functional connectivity in several brain networks.
Post-training, the active group exhibited greater resting-state functional connectivity between the basal ganglia, motor cortical, and cerebellar areas compared to the control group.
Lower resting-state functional connectivity was noted in the active group between specific brain regions, including the pedunculopontine nucleus and cerebellar areas.
Simplified
BACKGROUND: Physical activity combined with virtual reality and exergaming has emerged as a new technique to improve engagement and provide clinical benefit for gait and balance disorders in people with Parkinson's disease (PD).
OBJECTIVE: To investigate the effects of a training protocol using a home-based exergaming system on brain volume and (rs-FC) in persons with PD.
METHODS: A single blind randomized controlled trial was conducted in people with PD with gait and/or balance disorders. The experimental (active) group performed 18 training sessions at home by playing a custom-designed exergame with full body movements, standing in front of a RGB-D Kinectmotion sensor, while the control group played using the computer keyboard. Both groups received the same training program. Clinical scales, gait recordings, and brain MRI were performed before and after training. We assessed the effects of both training on both the grey matter volumes (GVM) and rs-FC, within and between groups. ®
RESULTS: Twenty-three patients were enrolled and randomly assigned to either the active (n = 11) or control (n = 12) training groups. Comparing pre- to post-training, the active group showed significant improvements in gait and balance disorders, with decreased rs-FC between the sensorimotor, attentional and basal ganglia networks, but with an increase between the cerebellar and basal ganglia networks. In contrast, the control group showed no significant changes, and rs-FC significantly decreased in the mesolimbic and visuospatial cerebellar and basal ganglia networks. Post-training, the rs-FC was greater in the active relative to the control group between the basal ganglia, motor cortical and cerebellar areas, and bilaterally between the insula and the inferior temporal lobe. Conversely, rs FC was lower in the active relative to the control group between the pedunculopontine nucleus and cerebellar areas, between the temporal inferior lobes and the right thalamus, between the left putamen and dorsolateral prefrontal cortex, and within the default mode network.
CONCLUSIONS: Full-body movement training using a customized exergame induced brain rs-FC changes within the sensorimotor, attentional and cerebellar networks in people with PD. Further research is needed to comprehensively understand the neurophysiological effects of such training approaches. Trial registration ClinicalTrials.gov NCT03560089.
Key numbers
11 of 12 patients
Improvement in gait and balance disorders
Active group showed improvement after training.
16 patients
Participants analyzed for MRI data
Pre- and post-training MRI datasets were analyzed.
Full Text
We can’t show the full text here under this license.
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
PubMed
Weekly Longevity & Aging Brief
You found one interesting study. We’ll send the next 7.
Get 7 new longevity & aging papers each week, explained in plain English with direct links to the originals.
