The bZIP transmembrane protein CREBH and its possible role in non-alcoholic fatty liver disease

Cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H (CREBH) is activated by endoplasmic reticulum stress and is associated with non-alcoholic fatty liver disease (NAFLD).

• CREBH is a transcription factor found in the endoplasmic reticulum membrane.
• Activation of CREBH occurs in response to endoplasmic reticulum stress, signaling related to liver glucose and lipid metabolism, and inflammation.
• CREBH may play a crucial role in regulating physiological functions linked to the development of NAFLD.
• The involvement of CREBH in NAFLD suggests it could serve as a potential target for pharmacological interventions.

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